Important Papers

[1] piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

  • Alyson Ashe et al.
  • Cell, Volume 150, Issue 1, 6 July 2012, Pages 88–993
  • Transgenerational effects have wide-ranging implications for human health, biological adaptation, and evolution; however, their mechanisms and biology remain poorly understood.
  • Here, they demonstrate that a germline nuclear small RNA/chromatin pathway can maintain stable inheritance for many generations when triggered by a piRNA-dependent foreign RNA response in C. elegans.
  • Using forward genetic screens and candidate approaches, they find that a core set of nuclear RNAi and chromatin factors is required for multigenerational inheritance of environmental RNAi and piRNA silencing.
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